The Effect of Ribavirin on Bone Density in Children with Chronic Hepatitis C Treated with Interferon-Ribavirin
The objective of the present study, conducted in Turkey, was to investigate the effects of ribavirin on bone mineral metabolism in patients with chronic hepatitis C who had been treated with interferon and ribavirin.
Twenty patients (3 female, 17 male) with chronic hepatitis C were enrolled. Age range was 6 to 15 years.
Thirteen patients received combined interferon alfa-2b and ribavirin therapy (Group 1), and 7 patients received only interferon alpha-2b (Group 2). Both groups were treated for 12 months.
Bone mineral density, z-scores and biochemical bone markers were evaluated in both groups before and after treatment.
The authors conclude, Contrary to studies in adults, we did not find any ribavirin-dependent changes related to bone mineral metabolism in our pediatric study groups.
Further studies are needed to obtain more detailed information about the effects of ribavirin on bone mineral density.
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