Gene Response to Interferon Therapy for Hepatitis C Differs by Race
Several studies have shown that individuals of African
descent respond less well to interferon-based therapy for chronic
hepatitis C, with a significantly lower proportion of black than white
patients achieving sustained virological response.
"Both treatment outcome and race are associated with different
transcriptional responses to interferon-alpha," the authors concluded.
"Because this difference is evident in the global induction of
interferon-stimulated genes rather than a selective effect on a subset of
such genes, key factors affecting the outcome of interferon-alpha therapy
are likely to act at the JAK-STAT pathway that controls transcription of
downstream interferon-stimulated genes."
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