Hepatitis C Association, Hepatitis C awareness, education support. Hep C information and su pport
Click here to print this page  
Previous Page

Hepatitis C Virus Infection Contributes to Gallstone Formation

Bile duct damage and hepatic steatosis are two characteristic histological findings in hepatitis C virus infection, and high prevalence of hepatitis C antibody is noted in patients with cholangiocarcinoma. The purpose of the present study was to examine the relationship between biliary diseases and hepatitis C virus infection.

Persons who received a general checkup in Chang Gung Memorial Hospital between 2000 and 2002 were included. All had hemogram, serum biochemistry, hepatitis B surface antigen, hepatitis C antibody and ultrasonography studies.

The prevalence of gallbladder stone, bile duct stone and gallbladder polyp/cholesterolosis were compared in different viral infection groups.


  • Of the 28 486 persons, 22 967 were negative for both hepatitis B surface antigen and hepatitis C antibody (group NBNC), 4152 were hepatitis B surface antigen carriers (group B), 1195 were positive for hepatitis C antibody (group C), and 172 were positive for both markers.

  • The 379 persons (1.3%) having had cholecystectomy were considered to have gallbladder stone at the time when cholecystectomy was done.

  • Gallbladder stone was found in 6.0% persons of group NBNC, 5.4% in group B and 11.7% in group C.

  • The prevalence of gallbladder stone in group C was found especially high for age groups 31-40 years and 61-70 years.

  • The prevalence of bile duct stone was higher in group C (0.4%) than in group NBNC or B (both 0.1%).

  • Stepwise logistic regression analysis showed that age, liver cirrhosis, body mass index, hepatitis C virus infection and gender were independent factors associated with gallbladder stone.
The authors conclude, “Hepatitis C virus infection facilitates gallstone formation.”

Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan.

T S Chang and others. Hepatitis C virus infection facilitates gallstone formation. Journal of Gastroenterology and Hepatology 9:1416-1421. September 20, 2005.


Print this page   Previous Page
  Home | What is hepatitis? | Our Mission | Who's Involved | Hepatitis C News | Upcoming Events | Brochures | Gift Cards |
HCV Awareness Items
| Related Links | From the CEO | To Whom It May Concern |
Bulletins | Message Board | Webrings & Awards | Contact Information
  Copyright © Hepatitis C Association Inc.  All rights reserved.